Grants
Ongoing research support:
Enhancing and making Biomarker Knowledge FAIR using contextual CFDE data
This proposal develops BiomarkerKB to refine biomarker data models with EDRN collaboration, enabling systems-level exploration of biomarkers for cancers and other diseases through AI-ready datasets and linked data tools. Budget ~ $450,000.
| PI: | Raja Mazumder |
| Sponsor: | |
| Period: | 09/17/2024 – 08/31/2027 |
Illuminating the Druggable Genome Data Coordinating Center – Engagement Plan with the CFDE
This proposal supports the IDG consortium by advancing tools like TCRD and Pharos to study understudied proteins and collaborating with CFDE to ensure data longevity and enable drug target discovery. Budget ~ $300,000.
| PI: | Christophe G Lambert, Jeremy Yang, Joseph |
| Sponsor: | |
| Period: | 09/23/2024 – 09/22/2025 |
Develop unsupervised Machine Learning and Artificial Intelligence to select antivirals against alphavirals
This proposal uses ML/AI to identify antiviral compounds for encephalitic alphaviruses, optimizing ADMET and efficacy through iterative testing. Budget ~ $450,000.
| PI: | Steven Bradfute, Christophe G Lambert |
| Sponsor: | DTRA (HDTRA1-15-1-006) |
| Period: | 12/2022 – 11/2027 |
Deriving high-quality evidence from national healthcare databases to improve suicidality detection and treatment outcomes in PTSD
This proposal is focused on understanding PTSD in Veterans and its association with self- harm, to aid in new discoveries of treatments. Budget ~ $750,000
| PI: | Christophe G Lambert |
| Sponsor: | |
| Period: | 12/23/2022 – 11/30/2026 |
Past research support:
Illuminating The Druggable Genome Data Coordinating Center – Engagement Plan with the CFDE
This proposal seeks to facilitate the discovery of new druggable targets. Budget ~$1.5M
| PI: | Christophe G Lambert, Avi Ma’ayan |
| Sponsor: | |
| Period: | 09/23/2020 – 09/22/2023 |
Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)
This proposal is focused on advancing research to study human proteins in order to catalyze the discovery of novel biology with a particular focus on understudied members of the protein kinase, ion channel, and non-olfactory GPCR families. Budget ~$3.2M
| PI: | Stephan C. Schrüer, Tudor I Oprea, Larry A. Skylar |
| Sponsor: | |
| Period: | 12/01/2017 – 11/30/2023 |
Ligand Specificity In Human Glucose Transporters GLUT1-5 and GLUT9
This proposal research is significant, because it is expected to lead to discovery of novel inhibitors and alternate substrates for GLUT1-5 and 9, and illuminate the molecular determinants of the functional variability within the GLUT family. Budget ~$1.3M
| PI: | Jun-Yong Choe, Tudor I Oprea, Mislav Oreb |
| Sponsor: | |
| Period: | 04/01/2017 – 03/31/2023 |
Illuminating The Druggable Genome Knowledge Management Center
This proposal seeks to facilitate the discovery of new druggable targets. Budget ~$4.9M
| PI: | Tudor Oprea |
| Sponsor: | NIH (1U54CA189205-01) |
| Period: | 08/01/14 – 6/30/16 |
Molecular Libraries Bioactivity Database (MLBD) – U54 supplement
This supplement aims to maximize return on the chemical biology investment of the Roadmap by reshaping knowledge management at NIH (“MLBD”). Budget ~$8.5M. Oprea wrote the UNM part of the proposal related to BARD
| PI: | Stuart Schreiber, Chris Austin, Larry Sklar |
| Sponsor: | NIH (1U54MH084690) |
| Period: | 31/1/2012 – 05/31/2015 |
OpenPHACTS
This consortium involves 14 academic partners and 8 major pharmaceutical companies, and aims to establish transparent, effective, semantic-web compliant technologies for data and knowledge mining. Budget ~$7M (Euro). Oprea was part of the 4-people core team that wrote the grant.
| PI: | Gerhard F Ecker (Uni Vienna); PI for DTU: T. Oprea |
| Sponsor: | Innovative Medicines Initiative (EU) |
| Period: | 3/01/2011 – 2/28/2014 |
Chemical Pattern Detection and Visualization in Biological Networks
This proposal seeks to develop bioactivity visualization tools in Cytoscape. Budget ~$500,000
| PI: | Tudor Oprea |
| Sponsor: | NIH (5R21GM095952-02) |
| Period: | 1/01/2011 – 11/30/2012 |
Development of GPR30-Selective Ligands
This proposal seeks to identify novel GPR30 agonists and antagonists. Budget ~$1.4
| MPI: | Jeffrey Arterburn, Tudor Oprea, Eric Prossnitz (Multiple PIs) |
| Sponsor: | NIH (R01CA127731-01A2) |
| Period: | 12/01/2007 – 11/30/2012 |
University of New Mexico Center for Molecular Discovery
This facility core provides informatics infrastructure support to the UNMCMD. Budget $15M
| PI: | Larry Sklar; Co-PI and Informatics core director: Tudor Oprea |
| Sponsor: | NIH (1U54MH084690) |
| Period: | 7/1/2008 – 5/28/2012 |