Research Identifiers
ORCID iD:
https://orcid.org/0000-0002-8041-0370
Education and qualifications (2)
University of California, San Diego: CA, CA, US
Organization identifiers
FUNDREF:
http://dx.doi.org/10.13039/100007911
University of California, San Diego : CA, CA, US
Department
Chemistry
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
University of New Mexico: Albuquerque, New Mexico, US
Department
Chemistry
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Unsupervised Latent Pattern Analysis for Estimating Type 2 Diabetes Risk in Undiagnosed Populations
2025-10-12 | Conference paper
Contributors:
Praveen Kumar; Vincent T. Metzger; Scott Alexander Malec
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Homepage URL
Contributors
Praveen Kumar
(Author)
Vincent T. Metzger
(Author)
Scott Alexander Malec
(Author)
External identifiers
Added
2025-12-10
Last modified
2025-12-10
Source:
Crossref
Crossref
KG2ML: Integrating Knowledge Graphs and Positive Unlabeled Learning for Identifying Disease-Associated Genes
2025-03-17 | Preprint
Contributors:
Praveen Kumar; Vincent T. Metzger; Swastika T. Purushotham; Priyansh Kedia; Cristian G. Bologa (and 2 more)
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Homepage URL
Contributors
Praveen Kumar
(Author)
Vincent T. Metzger
(Author)
Swastika T. Purushotham
(Author)
Priyansh Kedia
(Author)
Cristian G. Bologa
(Author)
Christophe G. Lambert
(Author)
Jeremy J. Yang
(Author)
External identifiers
Added
2025-03-20
Last modified
2025-10-23
Source:
Crossref
Crossref
Pharos 2023: an integrated resource for the understudied human proteome
Nucleic Acids Research
2023-01-06 | Journal article
DOI:
10.1093/nar/gkac1033
Contributors:
Keith J Kelleher; Timothy K Sheils; Stephen L Mathias; Jeremy J Yang; Vincent T Metzger (and 12 more)
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Homepage URL
Contributors
Keith J Kelleher
(Author)
Timothy K Sheils
(Author)
Stephen L Mathias
(Author)
Jeremy J Yang
(Author)
Vincent T Metzger
(Author)
Vishal B Siramshetty
(Author)
Dac-Trung Nguyen
(Author)
Lars Juhl Jensen
(Author)
Dušica Vidović
(Author)
Stephan C Schürer
(Author)
Jayme Holmes
(Author)
Karlie R Sharma
(Author)
Ajay Pillai
(Author)
Cristian G Bologa
(Author)
Jeremy S Edwards
(Author)
Ewy A Mathé
(Author)
Tudor I Oprea
(Author)
External identifiers
DOI:
10.1093/nar/gkac1033
Added
2022-11-29
Last modified
2023-01-08
Source:
Crossref
Crossref
Getting Started with the IDG KMC Datasets and Tools
Current Protocols
2022-01 | Journal article
DOI:
10.1002/cpz1.355
Contributors:
Vincent Metzger
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Homepage URL
Contributors
Vincent Metzger
(Author)
[ORCID: 0000-0002-8041-0370]
External identifiers
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Vincent T. Metzger
Electrostatic Channeling in P. falciparum DHFR-TS: Brownian Dynamics and Smoluchowski Modeling
Homepage URL
Contributors
Vincent Metzger
(Author)
[ORCID: 0000-0002-8041-0370]
External identifiers
ISSN:
0006-3495
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Vincent T. Metzger
A model study of sequential enzyme reactions and electrostatic channeling
The Journal of Chemical Physics
2014-03-14 | Journal article
DOI:
10.1063/1.4867286
Contributors:
Vincent Metzger
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Homepage URL
Contributors
Vincent Metzger
(Author)
[ORCID: 0000-0002-8041-0370]
External identifiers
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Vincent T. Metzger
Activation and dynamic network of the M2 muscarinic receptor
Proceedings of the National Academy of Sciences
2013-07-02 | Journal article
Contributors:
Vincent Metzger
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Contributors
Vincent Metzger
(Author)
[ORCID: 0000-0002-8041-0370]
External identifiers
Abstract
G-protein-coupled receptors (GPCRs) mediate cellular responses to various hormones and neurotransmitters and are important targets for treating a wide spectrum of diseases. Although significant advances have been made in structural studies of GPCRs, details of their activation mechanism remain unclear. The X-ray crystal structure of the M2 muscarinic receptor, a key GPCR that regulates human heart rate and contractile forces of cardiomyocytes, was determined recently in an inactive antagonist-bound state. Here, activation of the M2 receptor is directly observed via accelerated molecular dynamics simulation, in contrast to previous microsecond-timescale conventional molecular dynamics simulations in which the receptor remained inactive. Receptor activation is characterized by formation of a Tyr206
5.58
–Tyr440
7.53
hydrogen bond and ∼6-Å outward tilting of the cytoplasmic end of transmembrane α-helix 6, preceded by relocation of Trp400
6.48
toward Phe195
5.47
and Val199
5.51
and flipping of Tyr430
7.43
away from the ligand-binding cavity. Network analysis reveals that communication in the intracellular domains is greatly weakened during activation of the receptor. Together with the finding that residue motions in the ligand-binding and G-protein-coupling sites of the apo receptor are correlated, this result highlights a dynamic network for allosteric regulation of the M2 receptor activation.
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Vincent T. Metzger
Calcium binding and allosteric signaling mechanisms for the sarcoplasmic reticulum Ca<sup>2+</sup>ATPase
Protein Science
2012-10 | Journal article
DOI:
10.1002/pro.2129
Contributors:
Vincent Metzger
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Homepage URL
Contributors
Vincent Metzger
(Author)
[ORCID: 0000-0002-8041-0370]
External identifiers
DOI:
10.1002/pro.2129
ISSN:
0961-8368
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Vincent T. Metzger
Autonomous Targeting of Infectious Superspreaders Using Engineered Transmissible Therapies
PLoS Computational Biology
2011-03-17 | Journal article
Contributors:
Vincent Metzger
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Homepage URL
Contributors
Vincent Metzger
(Author)
[ORCID: 0000-0002-8041-0370]
External identifiers
ISSN:
1553-7358
Added
2022-09-12
Last modified
2022-09-12
Source:
Vincent T. Metzger
Vincent T. Metzger