Grants
Ongoing research support:
Deriving high-quality evidence from national healthcare databases to improve suicidality detection and treatment outcomes in PTSD
This proposal is focused on understanding PTSD in Veterans and its association with self- harm, to aid in new discoveries of treatments. Budget ~ 750,000
| PI: | Christophe G Lambert |
| Agency: | |
| Period: | 12/23/2022 – 11/30/2026 |
Illuminating The Druggable Genome Data Coordinating Center – Engagement Plan with the CFDE
This proposal seeks to facilitate the discovery of new druggable targets. Budget ~$1.5M
| PI: | Christophe G Lambert, Avi Ma’ayan |
| Agency: | |
| Period: | 09/23/2020 – 09/22/2023 |
Illuminating the Druggable Genome Resource Dissemination and Outreach Center (IDG-RDOC)
This proposal is focused on advancing research to study human proteins in order to catalyze the discovery of novel biology with a particular focus on understudied members of the protein kinase, ion channel, and non-olfactory GPCR families. Budget ~$3.2M
| PI: | Stephan C. Schrüer, Tudor I Oprea, Larry A. Skylar |
| Agency: | |
| Period: | 12/01/2017 – 11/30/2023 |
Ligand Specificity In Human Glucose Transporters GLUT1-5 and GLUT9
This proposal research is significant, because it is expected to lead to discovery of novel inhibitors and alternate substrates for GLUT1-5 and 9, and illuminate the molecular determinants of the functional variability within the GLUT family. Budget ~$1.3M
| PI: | Jun-Yong Choe, Tudor I Oprea, Mislav Oreb |
| Agency: | |
| Period: | 04/01/2017 – 03/31/2023 |
Past research support:
Illuminating The Druggable Genome Knowledge Management Center
This proposal seeks to facilitate the discovery of new druggable targets. Budget ~$4.9M
| PI: | Tudor Oprea |
| Agency: | NIH 1U54CA189205-01 |
| Period: | 08/01/14 – 6/30/16 |
Molecular Libraries Bioactivity Database (MLBD) – U54 supplement
This supplement aims to maximize return on the chemical biology investment of the Roadmap by reshaping knowledge management at NIH (“MLBD”). Budget ~$8.5M. Oprea wrote the UNM part of the proposal related to BARD
| PI: | Stuart Schreiber, Chris Austin, Larry Sklar |
| Agency: | NIH 1U54MH084690 |
| Period: | 31/1/2012 – 05/31/2015 |
OpenPHACTS
This consortium involves 14 academic partners and 8 major pharmaceutical companies, and aims to establish transparent, effective, semantic-web compliant technologies for data and knowledge mining. Budget ~$7M (Euro). Oprea was part of the 4-people core team that wrote the grant.
| PI: | Gerhard F Ecker (Uni Vienna); PI for DTU: T. Oprea |
| Agency: | Innovative Medicines Initiative (EU) |
| Period: | 3/01/2011 – 2/28/2014 |
Chemical Pattern Detection and Visualization in Biological Networks
This proposal seeks to develop bioactivity visualization tools in Cytoscape. Budget ~$500,000
| PI: | Tudor Oprea |
| Agency: | NIH 5R21GM095952-02 |
| Period: | 1/01/2011 – 11/30/2012 |
Development of GPR30-Selective Ligands
This proposal seeks to identify novel GPR30 agonists and antagonists. Budget ~$1.4
| MPI: | Jeffrey Arterburn, Tudor Oprea, Eric Prossnitz (Multiple PIs) |
| Agency: | NIH R01CA127731-01A2 |
| Period: | 12/01/2007 – 11/30/2012 |
University of New Mexico Center for Molecular Discovery
This facility core provides informatics infrastructure support to the UNMCMD. Budget $15M
| PI: | Larry Sklar; Co-PI and Informatics core director: Tudor Oprea |
| Agency: | NIH 1U54MH084690 |
| Period: | 7/1/2008 – 5/28/2012 |