Jayme Holmes Publications (6)

DrugCentral 2018: an update

DrugCentral is a drug information resource (http://drugcentral.org) open to the public since 2016 and previously described in the 2017 Nucleic Acids Research Database issue. Since the 2016 release, 103 new approved drugs were updated. The following new data sources have been included: Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), FDA Orange Book information, L1000 gene perturbation profile distance/similarity matrices and estimated protonation constants. New and existing entries have been updated with the latest information from scientific literature, drug labels and external databases. The web interface has been updated to display and query new data. The full database dump and data files are available for download from the DrugCentral website.

Oxford Nucleic Acids Research
Oct 29, 2018

Unexplored therapeutic opportunities in the human genome

A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative.

Nature Review Drug Discovery
Mar 23, 2018


View Publication: Formalizing drug indications on the road to therapeutic intent

Therapeutic intent, the reason behind the choice of a therapy and the context in which a given approach should be used, is an important aspect of medical practice. There are unmet needs with respect to current electronic mapping of drug indications. For example, the active ingredient sildenafil has 2 distinct indications, which differ solely on dosage strength.

Oxford 
July 17, 2017


View Publication: Pharos Collating protein information to shed light on the druggable genome.

Pharos: Collating protein information to shed light on the druggable genome.

The ‘druggable genome’ encompasses several protein families, but only a subset of targets within them have attracted significant research attention and thus have information about them publicly available.

Nature Review Drug Discovery


View publication DrugCentral: online drug compendium.

DrugCentral: online drug compendium.
publication description
DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies.

Oxford 



View publication Unexplored opportunities in the druggable human genome

Unexplored opportunities in the druggable human genome

Much of biomedical research and the development of therapeutics is focused on a small fraction of the human genome, ignoring many disease-relevant proteins and the associated scientific and commercial opportunities. The National Institutes of Health (NIH) Illuminating the Druggable Genome programme aims to catalyse research around understudied targets.

Nature 

Jayme Holmes Publications