Cristian Bologa Ph.D. Publications: |PubMed| |Google Scholar| |NCBI| |Back to Publications|

Cristian Bologa, Ph.D.

Research Professor

Citation indices	All	Since 2012
Citations	2572	1621
h-index	24	19
i10-index	39	29

Title1–100	Cited by	Year
TIN-X: Target Importance and Novelty Explorer. DC Cannon, JJ Yang, SL Mathias, O Ursu, S Mani, A Waller, SC Schürer, … Bioinformatics (Oxford, England)		2017
Protein biomarker druggability profiling S Mani, D Cannon, R Ohls, T Oprea, S Mathias, K Ballard, O Ursu, … Journal of Biomedical Informatics 66, 241-247		2017
Drug Target Ontology to Classify and Integrate Drug Discovery Data Y Lin, S Mehta, HK McGinty, JP Turner, D Vidovic, M Forlin, A Koleti, … bioRxiv, 117564		2017
A comprehensive Map of molecular drug targets R Santos, O Ursu, A Gaulton, AP Bento, RS Donadi, CG Bologa, … Nature Reviews Drug Discovery 16 (1), 19-34	8	2017
Badapple: promiscuity patterns from noisy evidence JJ Yang, O Ursu, CA Lipinski, LA Sklar, TI Oprea, CG Bologa Journal of cheminformatics 8 (1), 1-14	3	2016
Pharos: Collating protein information to shed light on the druggable genome DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, … Nucleic acids research, gkw1072	2	2016
DrugCentral: online drug compendium O Ursu, J Holmes, J Knockel, CG Bologa, JJ Yang, SL Mathias, SJ Nelson, … Nucleic Acids Research, gkw993	4	2016
Impact of similarity threshold on the topology of molecular similarity networks and clustering outcomes G Zahoránszky-Kőhalmi, CG Bologa, TI Oprea Journal of cheminformatics 8 (1), 16	1	2016
Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen–Fluorogen Activating Protein Binding Pair Y Wu, SR Stauffer, RL Stanfield, PH Tapia, O Ursu, GW Fisher, … Journal of biomolecular screening 21 (1), 74-87		2016
Therapeutic options and emerging alternatives for multidrug resistant staphylococcal infections M Magana, A Ioannidis, E Magiorkinis, O Ursu, C G Bologa, … Current pharmaceutical design 21 (16), 2058-2072	6	2015
Ligand‐Directed Profiling of Organelles with Internalizing Phage Libraries AS Dobroff, R Rangel, L Guzman‐Roja, CC Salmeron, JG Gelovani, … Current Protocols in Protein Science, 30.4. 1-30.4. 30		2015
Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis DR Christianson, AS Dobroff, B Proneth, AJ Zurita, A Salameh, … Proceedings of the National Academy of Sciences 112 (8), 2521-2526	9	2015
CHEMICAL AND BIOLOGICAL DESCRIPTOR INTEGRATION IMPROVES COMPUTATIONAL MODELING OF IN VIVO RAT TOXICITY CG Bologa, U Oleg, L Halip, R CURPĂN, TI Oprea Revue roumaine du chimie 60 (2-3), 219		2015
BIOLOGICAL PROMISCUITY OF HTS HITS EVALUATED VIA CHEMICAL REACTIVITY DESCRIPTORS R CURPĂN, S Avram, L Halip, C Bologa Rev. Roum. Chim 60 (2-3), 205-211		2015
Defining the microbial effluxome in the content of the host-microbiome interaction A Ioannidis, M Magana, CG Bologa, TI Oprea, IT Paulsen, GP Tegos Frontiers in pharmacology 6		2015
FRET detection of lymphocyte function–associated antigen-1 conformational extension A Chigaev, Y Smagley, MK Haynes, O Ursu, CG Bologa, L Halip, T Oprea, … Molecular biology of the cell 26 (1), 43-54	2	2015
A high throughput flow cytometric assay platform targeting transporter inhibition GP Tegos, AM Evangelisti, JJ Strouse, O Ursu, C Bologa, LA Sklar Drug Discovery Today: Technologies 12, e95-e103	7	2014
Exploring the biological promiscuity of high-throughput screening hits through DFT calculations R Curpăn, S Avram, R Vianello, C Bologa Bioorganic & medicinal chemistry 22 (8), 2461-2468	8	2014
Emerging trends in the discovery of natural product antibacterials CG Bologa, O Ursu, TI Oprea, CE Melançon, GP Tegos Current opinion in pharmacology 13 (5), 678-687	25	2013
Data curation and formal BioAssay Ontology (BAO)-based annotations of the DrugMatrix enable bioactivity-based target-relationship analysis and demonstrate incorporation of external datasets into the BioAssay Research Database (BARD) T Oprea, S Schurer, A Mir, U Vempati, J Yang, O Ursu, C Bologa ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246		2013
Molecular scaffolds are special and useful guides to discovery JJ Yang, CG Bologa, DJ Wild, TI Oprea ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246		2013
BADAPPLE promiscuity plugin for BARD: Evidence-based promiscuity scores JJ Yang, O Ursu, CG Bologa, A Waller, LA Sklar, TI Oprea ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246	4	2013
Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters JJ Strouse, I Ivnitski-Steele, A Waller, SM Young, D Perez, AM Evangelisti, … Analytical biochemistry 437 (1), 77-87	19	2013
Cheminformatics aspects of high throughput screening: from robots to models: symposium summary YJ Tseng, E Martin, CG Bologa, AA Shelat Journal of computer-aided molecular design 27 (5), 443-453	2	2013
BioAssay Research Database: A platform to support the collection, management, and analysis of chemical biology data R Guha, D Lahr, J Bittker, TDY Chung, M Southern, S Chatwin, JJ Yang, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245		2013
A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7 L Hong, P Simons, A Waller, J Strouse, Z Surviladze, O Ursu, C Bologa, … National Center for Biotechnology Information (US)	7	2013
Selective Bcl-2 Inhibitor Probes J Zou, R Ardecky, AB Pinkerton, E Sergienko, Y Su, D Stonich, RF Curpan, … National Center for Biotechnology Information (US)	1	2013
Selective efflux inhibition of ATP-binding cassette sub-family G member 2 JJ Strouse, I Ivnitski-Steele, HM Njus, TD Foutz, T Yao, WS Weiner, … National Center for Biotechnology Information (US)	4	2013
Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway J Chen, SM Young, C Allen, A Waller, O Ursu, JJ Strouse, T Yao, … National Center for Biotechnology Information (US)	2	2013
The CARLSBAD database: a confederated database of chemical bioactivities SL Mathias, J Hines-Kay, JJ Yang, G Zahoransky-Kohalmi, CG Bologa, … Database 2013, bat044	9	2013
A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry JJ Strouse, I Ivnitski-Steele, HM Khawaja, D Perez, J Ricci, T Yao, … Journal of biomolecular screening 18 (1), 26-38	10	2013
A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6 K Polireddy, MMT Khan, H Chavan, S Young, X Ma, A Waller, M Garcia, … PloS one 7 (7), e40005	10	2012
Development of a screening informatics system at the UNM Center for Molecular Discovery, an NIH MLP specialty center JJ Yang, O Ursu, SL Mathias, CG Bologa, A Waller, AM Evangelisti, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 243		2012
CARLSBAD (Confederated Annotated Research Libraries for Small molecule BioActivity Data): A database and its platform G Zahoranszky-Kohalmi, JJ Yang, CG Bologa, SL Mathias, O Ursu, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 243		2012
Drug repurposing from an academic perspective TI Oprea, JE Bauman, CG Bologa, T Buranda, A Chigaev, BS Edwards, … Drug Discovery Today: Therapeutic Strategies 8 (3), 61-69	83	2012
Compound collection preparation for virtual screening CG Bologa, TI Oprea Bioinformatics and Drug Discovery, 125-143	4	2012
Identification of a small molecule yeast TORC1 inhibitor with a flow cytometry-based multiplex screen J Chen, SM Young, C Allen, A Seeber, MP Péli-Gulli, N Panchaud, …	9 *	2012
Of possible cheminformatics futures TI Oprea, O Taboureau, CG Bologa Journal of computer-aided molecular design 26 (1), 107-112	8	2012
Selective, privileged and promiscuous chemical patterns in high-throughput screening O Ursu, JJ Yang, RF Curpan, L Ostopovici-Halip, CA Lipinski, LA Sklar, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242		2011
Identification of a GPER/GPR30 Antagonist with Improved Estrogen Receptor Counterselectivity MK Dennis, AS Field, R Burai, C Ramesh, WK Petrie, CG Bologa, … The Journal of Steroid Biochemistry and Molecular Biology	129	2011
Structural determinants of the alpha2 adrenoceptor subtype selectivity. L Ostopovici-Halip, R Curpăn, M Mracec, CG Bologa Journal of molecular graphics & modelling 29 (8), 1030-1038	10	2011
Microbial efflux pump inhibition: tactics and strategies G P Tegos, M Haynes, J Jacob Strouse, M Md T Khan, C G Bologa, … Current pharmaceutical design 17 (13), 1291-1302	50	2011
Abstract LB-214: Rac1 and Cdc42 GTPases as novel targets in ovarian cancer A Wandinger-Ness, SR Kenney, J Agola, J Roxby, Z Surviladze, … Cancer Research 71 (8 Supplement), LB-214-LB-214		2011
Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer‐Aided Drug Repurposing TI Oprea, SK Nielsen, O Ursu, JJ Yang, O Taboureau, SL Mathias, … Molecular informatics 30 (2‐3), 100-111	67	2011
Compounds for binding to ERα/β and GPR30, methods of treating disease states and conditions mediated through these receptors and identification thereof ER Prossnitz, SE Tkatchenko, CM Revankar, LA Sklar, JB Arterburn, … US Patent 7,875,721	1	2011
Structural Simplification of Bioactive Natural Products with Multicomponent Synthesis. 3. Fused Uracil-Containing Heterocycles as Novel Topoisomerase-Targeting Agents NM Evdokimov, S Van slambrouck, P Heffeter, L Tu, B Le Calvé, … Journal of Medicinal Chemistry 54 (7), 2012-2021	32	2011
High-Throughput Screen for the Chemical Inhibitors of Antiapoptotic Bcl-2 Family Proteins by Multiplex Flow Cytometry RF Curpan, PC Simons, D Zhai, SM Young, MB Carter, CG Bologa, … ASSAY and Drug Development Technologies 9 (5), 465-474	15	2011
Three small molecule pan activator families of Ras-related GTPases Z Surviladze, O Ursu, F Miscioscia, R Curpan, L Halip, C Bologa, T Oprea, … National Center for Biotechnology Information (US)	7	2010
Model-free drug-like filters O Ursu, CG Bologa, TI Oprea ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 240		2010
Modulation of bitter taste perception by a small molecule hTAS2R antagonist JP Slack, A Brockhoff, C Batram, S Menzel, C Sonnabend, S Born, … Current Biology 20 (12), 1104-1109	90	2010
Promiscuity and PubChem: a retrospective analysis C Bologa Proceedings of the Society for Biomolecular Screening 16th Annual Conference …	2	2010
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs M Shorty, C Bologa, J B Arterburn, C Ramesh, L A Sklar, E R Prossnitz, … The Royal Society of Chemistry		2010
Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs R Burai, C Ramesh, M Shorty, R Curpan, C Bologa, LA Sklar, T Oprea, … Organic & biomolecular chemistry 8 (9), 2252-2259	27	2010
A Potent and Selective Inhibitor of Cdc42 GTPase Z Surviladze, A Waller, JJ Strouse, C Bologa, O Ursu, V Salas, …	46	2010
High‐Throughput Flow Cytometry LA Sklar, PC Simons, A Waller, SM Biggs, SM Young, M Olah, C Bologa, … Pharmaceutical Sciences Encyclopedia: Drug Discovery, Development, and …	1	2010
Study of a Trisazo Direct Dye Adsorption on Wood Fibre Using a Comparison of Different Adsorption Isotherms SG MUNTEAN, G SIMU, P SFARLOAGA, C BOLOGA	3	2010
Conformational mAb as a tool for integrin ligand discovery BH Njus, A Chigaev, A Waller, D Wlodek, L Ostopovici-Halip, O Ursu, … Assay and drug development technologies 7 (5), 507-515	16	2009
A crowdsourcing evaluation of the NIH chemical probes (vol 5, pg 441, 2009) TI Oprea, CG Bologa, S Boyer, RF Curpan, RC Glen, AL Hopkins, … NATURE CHEMICAL BIOLOGY 5 (8), 600-600		2009
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt® high-throughput flow cytometry system MK Haynes, JJ Strouse, A Waller, A Leitao, RF Curpan, C Bologa, … Journal of biomolecular screening 14 (6), 596-609	17	2009
A crowdsourcing evaluation of the NIH chemical probes TI Oprea, CG Bologa, S Boyer, RF Curpan, RC Glen, AL Hopkins, … Nature chemical biology 5 (7), 441-447	89	2009
In vivo effects of a GPR30 antagonist MK Dennis, R Burai, C Ramesh, WK Petrie, SN Alcon, TK Nayak, … Nature chemical biology 5 (6), 421-427	321	2009
Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation A Chigaev, A Waller, O Amit, L Halip, CG Bologa, LA Sklar Journal of Biological Chemistry 284 (21), 14337-14346	42	2009
High-throughput screening of small molecule inducers of autophagy as potential therapies for prostate cancer D MacKenzie, M Haynes, CA Hu, L Skalr, T Oprea, C Bologa, … CANCER RESEARCH 69	2	2009
Abstract# 5505: High-throughput screening of small molecule inducers of autophagy as potential therapies for prostate cancer D MacKenzie, M Haynes, CA Hu, L Sklar, T Oprea, C Bologa, … Cancer Research 69 (9 Supplement), 5505-5505		2009
Duplex high‐throughput flow cytometry screen identifies two novel formylpeptide receptor family probes SM Young, CM Bologa, D Fara, BK Bryant, JJ Strouse, JB Arterburn, … Cytometry Part A 75 (3), 253-263	30	2009
COMP 30-HTS and pharmacology of multiplexed small GTPase targets by flow cytometry LA Sklar, Z Surviladze, GM Bokoch, CG Bologa, B Edwards, TI Oprea, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 236		2008
COMP 141-Promiscuous patterns and perils in the NIH Molecular Libraries Initiative JJ Yang, CG Bologa, TI Oprea ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 236		2008
CINF 27-RoadRunner: A publicly available bioactivity database TI Oprea, SL Mathias, JJ Yang, CG Bologa ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 235		2008
High-throughput flow cytometry for drug discovery BS Edwards, SM Young, MJ Saunders, C Bologa, TI Oprea, RD Ye, … Expert opinion on drug discovery 2 (5), 685-696	26	2007
Integration of virtual and physical screening DC Fara, TI Oprea, ER Prossnitz, CG Bologa, BS Edwards, LA Sklar Drug Discovery Today: Technologies 3 (4), 377-385	24	2007
Lead-like, drug-like or “Pub-like”: how different are they? TI Oprea, TK Allu, DC Fara, RF Rad, L Ostopovici, CG Bologa Journal of computer-aided molecular design 21 (1-3), 113-119	99	2007
The spectator role of potassium hydroxide in the isomerisation of eugenol to isoeugenol CC Galopin, C Bologa, WB DeVoe Developments in Food Science 43, 229-232		2006
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform BS Edwards, SM Young, TI Oprea, CG Bologa, ER Prossnitz, LA Sklar NATURE PROTOCOLS-ELECTRONIC EDITION- 1 (1), 59	29	2006
Flow cytometry and the NIH Roadmap Molecular Libraries Screening Initiative BS Edwards, J Arterburn, S Biggs, C Bologa, T Buranda, D Cimino, … CYTOMETRY PART A 69 (5), 409-409		2006
Virtual and biomolecular screening converge on a selective agonist for GPR30 CG Bologa, CM Revankar, SM Young, BS Edwards, JB Arterburn, … Nature chemical biology 2 (4), 207-212	566	2006
Dissociation energy computations for saline bonds implied in interactions mediated by peptidoglicans S Muntean, L Kurunczi, C Bologa, G Ilia, Z Simon Macromolecular symposia 235 (1), 215-219	3	2006
QSAR and Molecular Modelling in Rational Design of Bioactive Molecules TI Oprea, MA Kappler, TK Allu, M Mracec, MM Olah, R Rad, L Ostopovici, … Computer Aided Drug Design & Development Society in Turkey	4	2006
Chemical database preparation for compound acquisition or virtual screening CG Bologa, MM Olah, TI Oprea Bioinformatics and Drug Discovery, 375-388	21	2006
Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists BS Edwards, C Bologa, SM Young, KV Balakin, ER Prossnitz, … Molecular pharmacology 68 (5), 1301-1310	101	2005
Descriptor collision and confusion: Toward the design of descriptors to mask chemical structures C Bologa, TK Allu, M Olah, MA Kappler, TI Oprea Journal of computer-aided molecular design 19 (9), 625-635	14	2005
Post-high-throughput screening analysis: an empirical compound prioritization scheme TI Oprea, CG Bologa, BS Edwards, ER Prossnitz, LA Sklar Journal of biomolecular screening 10 (5), 419-426	19	2005
High-throughput screening with HyperCyt® flow cytometry to detect small molecule formylpeptide receptor ligands SM Young, C Bologa, ER Prossnitz, TI Oprea, LA Sklar, BS Edwards Journal of biomolecular screening 10 (4), 374-382	59	2005
Compound selection for virtual screening TI Oprea, C Bologa, M Olah Virtual Screening in Drug Discovery, 89-106	11	2005
Dissociation of I Domain and Global Conformational Changes in LFA-1: Refinement of Small Molecule-I Domain Structure− Activity Relationships RS Larson, T Davis, C Bologa, G Semenuk, S Vijayan, Y Li, T Oprea, … Biochemistry 44 (11), 4322-4331	41	2005
Confusing descriptors: Where chemical information gets dizzy. CG Bologa, M Olah, TI Oprea ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 229, U762-U762		2005
Mapping bioactivity space for fragment-based lead discovery TI Oprea, M Olah, M Mracec, R Rad, L Ostopovici, A Bora, N Hadaruga, … ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 229, U157-U157	1	2005
Quantitative structure-activity relationship by CoMFA for cyclic urea and nonpeptide-cyclic cyanoguanidine derivatives on wild type and mutant HIV-1 protease S Avram, C Bologa, ML Flonta Journal of molecular modeling 11 (2), 105-115	8	2005
Virtual screening in drug discovery TI Oprea, C Bologa, M Olah, J Alvarez, BK Shoichet Taylor & Francis, Boca Raton	4 *	2005
Strategies for compound selection MM Olah, CG Bologa, TI Oprea Current drug discovery technologies 1 (3), 211-220	74	2004
An automated PLS search for biologically relevant QSAR descriptors M Olah, C Bologa, TI Oprea Journal of computer-aided molecular design 18 (7-9), 437-449	82	2004
Screening with HyperCyt (R) high-throughput flow cytometry to detect small-molecule formyl-peptide receptor ligands BS Edwards, SM Young, A Waller, C Bologa, T Oprea, ER Prossnitz, … CYTOMETRY PART A 59 (1), 31-32		2004
Priori vs. A posteriori: An exhaustive PLS search for biologically-relevant QSAR descriptors. TI Oprea, CG Bologa ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 227, U904-U905		2004
Correlation between the predicted and the observed biological activity of the symmetric and nonsymmetric cyclic urea derivatives used as HIV‐1 protease inhibitors. A 3D‐QSAR‐CoMFA method for new antiviral drug design S Avram, I Svab, C Bologa, ML Flonta Journal of cellular and molecular medicine 7 (3), 287-296	16	2003
Application of computer assisted combinatorial chemistry in antivirial, antimalarial and anticancer agents design E Burello, C Bologa, V Frecer, S Miertus Molecular physics 100 (19), 3187-3198	4	2002
MTD-PLS: A PLS-Based Variant of the MTD Method. 2. Mapping Ligand− Receptor Interactions. Enzymatic Acetic Acid Esters Hydrolysis L Kurunczi, M Olah, TI Oprea, C Bologa, Z Simon Journal of chemical information and computer sciences 42 (4), 841-846	17	2002
Significance of MTD and other descriptors in lipophilicity models for chlorinated aromatic compounds M Mracec, M Mracec, C Bologa, Z Simon SAR and QSAR in Environmental Research 12 (1-2), 143-158	2	2001
A quantitative structure-activity relationship study used to predict the biological activity of the HIV-1 protease cyclic urea inhibitors S Avram, C Bologa, M Banda, ML Flonta Rom. J. Biophys 11, 11	5	2001
Possible saline bonds in peptidoglycan interactions. Steric considerations and sulphate and carbonate solubilities V Careja, M Banda, L Saity, C Bologa, M Mracec, Z Simon Proc. Rom. Acad.(ser. B) 2, 187-190	5	2000
Phenylaziridine as a 1, 3-dipole. Application to the synthesis of functionalized pyrrolidines I Ungureanu, C Bologa, S Chayer, A Mann Tetrahedron letters 40 (29), 5315-5318	52	1999
QSAR for cycloaliphatic alcohols with qualitatively defined sandalwood odour characteristics DI Hadaruga, S Muresan, C Bologa, A Chiriac, Z Simon, L Cofar, … Quantitative structure-activity relationships 18 (3), 253-261	13	1999